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phenobarbital will minimize the level or impact of olanzapine/samidorphan by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Steer clear of or Use Alternate Drug. Potent CYP3A4 inducers reduce levels of olanzapine and samidorphan by~fifty% and ~seventy five% respectively.phenobarbital decreases levels of bazedoxifene/conjugated estrogens by